LEP and atherosclerosis: Excessive production of inflammatory marker and oxidative stress could mediate the chronic disease and is correlated with the development of atherosclerotic lesions.1 Leptin, the adipocyte-derived molecule, has an important action to regulate energy balance and metabolism.23 Importantly, leptin may also exert actions to stimulate vascular inflammation and oxidative stress which may contribute to pathogenesis atherosclerosis and coronary heart disease.24 Our findings have indicated that bLF decreases the leptin levels in hypercholesteromic condition.