According to the epidemiological studies, the hyperlipidemia is characterized by hypercholesterolemia and high concentration of LDL-cholesterol (LDL-C) which are important denominators and major factors in atherosclerosis occurrence and development.13 In this research, we showed that bLF could decrease serum Hcy and leptin levels which are known as the main risk factors related to atherosclerosis complication. The gene discussed is LEP; the disease is Hypercholesterolemia.