Oxidative stress and inflammation are two main causes of CVD .Several studies have demonstrated that leptin contributes to endothelial dysfunction, heart failure and myocardial infarction via the secretion of some pro-inflammatory cytokines and oxidative stress.5 The correlation between elevated leptin levels and the formation of reactive oxygen species, fatty acid oxidation and activation of protein kinase A in bovine aortic endothelial cells were indicated by studies.6 This evidence concerns the gene LEP and endothelial dysfunction.