The study of MADIT-CRT showed that the increased Gal-3 level is an independent predictor of an unfavourable outcome in patients with moderate CHF.29 However, CARE-HF studies showed no Gal-3 level changes after CRT.30 In BIOCRT study predictor ability of GAL-3 in the complex with NT-proBNP and sST241 was compared. The gene discussed is LGALS3; the disease is hydrops fetalis.