EGFR and non-small cell lung carcinoma: However, clinical data showed that the efficacy of neratinib for NSCLC was poor and low efficacy of neratinib for NSCLC patients had been observed in a phase II trial: NSCLC patients were assigned to group A (EGFR mutation, n = 91), group B (wild-type EGFR, n = 48), and group C (TKI-naïve, n = 28).