In an open-label, randomized, multicenter, phase II study, 154 patients with advanced NSCLC with activating EGFR mutations randomly received erlotinib (150 mg/day) monotherapy or erlotinib (150 mg/day) plus bevacizumab (150 mg/kg) as a first-line therapy. This evidence concerns the gene EGFR and non-small cell lung carcinoma.