Although the regulatory mechanisms underlying Wnt/Dkk-3 – induced apoptosis remain to be elucidated, Abarzua et al., [28] showed that overexpression of Dkk-3 selectively induced apoptotic cell death in human prostate cancer cells via activation of c-Jun-NH2-kinase (JNK). This evidence concerns the gene MAPK8 and Familial prostate cancer.