In this study, by Western Blot analysis, we confirmed that TLR-4 was significantly increased in GBM patients tissue (Figure 10D) respect to control brain tissue (Figure 10D), suggesting that the use of a TLR-4 antagonist could be able to induce anti-proliferative and antimigratory response in glioma tumors. This evidence concerns the gene TLR4 and glioma.