TLR4 and neoplasm: Moreover, tumors sections from control mice, stained with hematoxylin – eosin (H/E) showed subcutaneous masses, composed of solid sheets and nests of irregularly round epithelioid cells with prominent round to ovoid nuclei with ill-defined cell borders, as well as an increase of tumor necrosis and neutrophilic infiltration; indeed TLR-4 KO mice showed a significantly reduction of tumor sections (10–60% in TLR-4 KO compared to 50–80% from Control WT mice) as well as in neutrophil infiltration as shown in Figure 5E.