DKK3 and neoplasm: An evident positive staining for Dkk-3 and claudin-5 was shown on TLR-4 KO tumor brain sections (Figure 6B–B1 and 6E–E1, see graphs respectively Figure 6C and 6F) compared to control WT section (Figure 6A–A1 and 6D–D1, see graphs respectively Figure 6C and 6F).