CASP3 and neoplasm: Consistent with these findings, in our study we observed a higher expression of Caspase-9 rather than the apoptotic Caspase-3, in human GBM cell lines respect to control cell, suggesting low apoptotic activity in these tumor cells and underling that the antiproliferative property of Dkk-3 was due to the modulation of caspase-dependent apoptosis.