An evident positive staining for Dkk-3 and claudin-5 was shown on TLR-4 KO tumor brain sections (Figure 6B–B1 and 6E–E1, see graphs respectively Figure 6C and 6F) compared to control WT section (Figure 6A–A1 and 6D–D1, see graphs respectively Figure 6C and 6F). This evidence concerns the gene TLR4 and neoplasm.