MSI-H colon cancer cases assessed by (1) on-chip electrophoresis of five satellite markers, (2) DNA sequencing of four exoninc MMR deficiency target mononucleotide repeats, and (3) IHC for four MMR proteins MLH1, MSH2, MSH6 and PMS2. This evidence concerns the gene MSH2 and mismatch repair cancer syndrome 1.