In the network analyses based on the profiles of SS18/SSX knockdown in SS cells, we identified several pathways involving RUNX2 and SMARCA4 that played a critical functional role and acted as upstream regulators of these proteins known to be associated with the SYT/SSX expression in SS cells (Supplementary Tables 4 and Table 5). The gene discussed is RUNX2; the disease is synovial sarcoma.