It has to be noted that breast cancer represents a heterogeneous disease, which becomes evident when studying IGF-I-R expression for instance: A meta-analysis about IGF-I-R expression in breast cancer had revealed that IGF-I-R overexpression was a favorable prognostic variable in unselected breast cancers, but lead to a reduced survival in triple-negative breast cancers [16]. This evidence concerns the gene IGF1R and triple-negative breast carcinoma.