Of note, comparative expression profiling of selected cHL patient samples indicated significant differences in gene activities of NKX2-2, FOXG1, NEUROD1 and SMURF2 (Supplementary Figure 5), demonstrating that parts of the described network in NLPHL-derived DEV are relevant in both NLPHL and cHL entities. This evidence concerns the gene NEUROD1 and classic Hodgkin lymphoma.