APC and colorectal carcinoma: However, even when the results of all three studies are taken together, APC missense variants are not enriched in CRC cases (4.5%) compared to individuals from the general population (8.9%) (based on the gnomAD-database where 12,267 alleles with rare (MAF ≤ 1%) APC missense variants were detected in exome and genome data of 138,632 individuals).