ERBB2 and gastric cancer: In 2016, the most commonly prescribed first-line chemotherapy regimens for HER2-negative or unknown status of GC or GEJC were FOLFOX (5-FU, calcium leucovorin and oxaliplatin), EOX and ECF in the US and in Europe, while TS-1 plus cisplatin and TS-1 plus oxaliplatin were mostly used in Japan [62].