AFP and neoplasm: In addition, tumor-related factors, including male patients (OR = 2.16, P = 0.004), AFP levels > 7.02 ng/ml (OR = 2.86, P < 0.001), tumor size > 3 cm (OR = 2.20, P < 0.001), Edmondson-Steiner histological grade III/IV (OR = 2.97, P = P < 0.001), tumor encapsulation incompleteness (OR = 1.96, P = 0.001), and presence of satellite nodules (OR = 3.60, P < 0.001) were significantly and independently related to the formation of microvessel invasion of cell carcinoma.