In order to find new biomarkers that may act as diagnostic biomarkers for endometrial cancer, we evaluated Jagged2 (JAG2), Aurora Kinase A (AURKA), Phosphoglycerate Kinase 1 (PGK1), and Hypoxanthine Guanine Phosphoribosyltransferase 1 (HPRT1) for their role in cellular proliferation and cancer development. This evidence concerns the gene HPRT1 and endometrial cancer.