PIGN and Fryns syndrome: A homozygous missense variant in PIGW (c.[106 A>G];[106 A>G], p.(R36G) that segregated in both fetuses was prioritized because phenotypes caused by variants in PIGV and PIGN genes of the PIG family show a phenotypic overlap with Fryns syndrome [21] or are described to be causal for the Fryns phenotype [22].