We completed a tubulointerstitial transcriptional analysis of 5 cases of FSGS and 5 normal controls, the level of LOC105375913 showed the maximum increase in the tubulointerstitial tissues of FSGS patients, and overexpression of LOC105375913 induced the expression of FN and Col I in tubular cells. This evidence concerns the gene FN1 and focal segmental glomerulosclerosis.