This includes Alzheimer’s disease, where HSP70 has been demonstrated to have cytoprotective roles in inhibition of Aß oligomerisation and by enhancing the clearance of Aß40,41 As SorLA is the first described substrate for HSPA12A, cellular and physiological roles for HSPA12A are poorly elucidated. The gene discussed is SORL1; the disease is early-onset autosomal dominant Alzheimer disease.