Within LPS-treated groups, both time (hypo: F1,84 = 48.4, p < 0.0001; frontal cortex: F1,87 = 70.4, p < 0.0001) and tumor treatment (hypo: F2,84 = 3.8, p < 0.05; frontal cortex: F2,87 = 4.9, p < 0.01) independently influenced hypothalamic and frontal cortex Il-6, as well as their interaction (hypo: F2,84 = 3.6, p < 0.05; frontal cortex: F2,87 = 4.9, p < 0.01). This evidence concerns the gene IL6 and neoplasm.