Indeed, we reproduced the above finding by combining dimerization data obtained from 293T cells exogenously expressing RAF dimer-probes (Fig. 2) with the paradoxical activation data obtained from cancer cell lines harbouring EGFR, KRAS or BRAF mutation (Fig. 4) and 293T cells overexpressing RAF isoforms (Supplementary Fig. S4). The gene discussed is KRAS; the disease is cancer.