KCNK3 and pulmonary arterial hypertension: As recently reviewed by Olschewski et al. 21, the contribution of alterations at ion channels to pulmonary hypertension is progressively emerging because they are supposed to play a pivotal role in both the triggering and the development of the disease, as demonstrated by the function of KCNA5 and KCNK3 in regulation of pulmonary vascular tone.