ATP13A3 and pulmonary arterial hypertension: Our data thus suggest that it could likely contribute to the initiation of PAH similar to KCNK3 and KCNA5. In line with these findings, in a very recent paper having analyzed 1,038 whole genome sequences from idiopathic and familial PAH, heterozygous mutations at ATP13A3 showing functional impact on protein catalytic activity were observed in 11 patients23.