Supporting this report, analysis of publically available expression levels of GSK3α and GSK3β using the BloodSpot database (which contains more than 2000 AML and normal samples assembled from six independent studies on AML) revealed that GSK3α is overexpressed across multiple AML subtypes as compared to normal hematopoietic lineages (Fig. S1a). This evidence concerns the gene GSK3B and acute myeloid leukemia.