We also predicted that the use of KYA1797K for the treatment of NSCLC will provide an additional advantage by inhibiting the Wnt/β-catenin pathway since activation of the Wnt/β-catenin pathway promotes hyper-proliferation of lung cancer cells and inhibition of the Wnt/β-catenin pathway synergizes the effect of EGFR inhibition17–19. The gene discussed is EGFR; the disease is lung carcinoma.