We hypothesized that KYA1797K, which destabilizes Ras via suppression of the Wnt/β-catenin pathway, may suppress growth of NSCLC tumors with aberrant activation of the EGFR-Ras-ERK pathway, including those resistant to EGFR TKIs due to KRAS mutations. The gene discussed is KRAS; the disease is non-small cell lung carcinoma.