EGFR and non-small cell lung carcinoma: In addition, a recent study identified that the Wnt/β-catenin pathway is one of the underlying pathways causing NSCLC relapse after treatment of EGFR-driven NSCLC with EGFR inhibitors, such as gefitinib and erlotinib, since the Wnt/β-catenin pathway works as a mechanism of protection from EGFR inhibition20.