EGFR and non-small cell lung carcinoma: We also predicted that the use of KYA1797K for the treatment of NSCLC will provide an additional advantage by inhibiting the Wnt/β-catenin pathway since activation of the Wnt/β-catenin pathway promotes hyper-proliferation of lung cancer cells and inhibition of the Wnt/β-catenin pathway synergizes the effect of EGFR inhibition17–19.