Among them, 25 harbored unmutated IGHV genes (UM-CLL) and expressed the ZAP70 protein (ZAP70+), 29 had mutated IGHV genes (M-CLL) and did not express the ZAP70 protein (ZAP70−), 10 were ZAP70 + M-CLL and one was ZAP70− UM-CLL. The gene discussed is ZAP70; the disease is B-cell chronic lymphocytic leukemia.