BCR and B-cell chronic lymphocytic leukemia: While CpG-ODN2006 alone did not induce CLL cells proliferation (for 35 out of 39 CLL cells tested), we observed increased responses (p < 0.0001) when cells were stimulated with CpG-ODN2006 combined to BCR and cytokines in soluble and 3D semi-solid medium (Fig. 4A–F).