The linear regression revealed a significant association between gmCBF and both APOE (β = −0.213, P = 0.044) and AD-PRS (β = −0.232, P = 0.031) controlling for age, gender and GMV (see Table 1 for full regression model; Fig. 1a,b for effect size estimates). The gene discussed is APOE; the disease is Alzheimer disease.