Having found robust effects of PAM on pathologically defined AD, and given the high degree of neuropathological heterogeneity found in our cohort9,10, we sought to identify whether effects of PAM were specific to β-amyloid (Aβ) and tau (the defining pathologic characteristics of AD) or were also associated with other neuropathological features commonly observed in aged individuals. Here, MAPT is linked to Alzheimer disease.