Thus, FGF19 and NGM282 appear to selectively modulate LXR signaling, upregulating canonical LXR target genes (Abcg5, Abcg8, Scarb1, Srebf1, Fasn, Scd1, Srebf2, and Scap) without inducing hepatic steatosis. This evidence concerns the gene SCAP and Hepatic steatosis.