PDX1 and type 2 diabetes mellitus: For example, urocortin 3l (ucn3l), pancreatic and duodenal homeobox 1 (pdx1), cacna1ha, sytl4 and the T2DM risk gene kcnj11, which encodes the components of the ATP-sensitive potassium (K-ATP) channel, were downregulated in the il1b-expressing β-cells.