In contrast, light avoidance using tinted spectacles may confer benefit in ABCA4-associated retinopathy by inhibiting A2E production,90 which produces DNA-damaging epoxides.91 Vitamin A should also be avoided in ABCA4-associated retinopathy as it may enhance A2E production and, therefore, disease progression.92 This evidence concerns the gene ABCA4 and retinal disorder.