In addition, overexpression of CXCR4 dramatically increased chronic inflammation and tumor burden, the number and size of colonic adenocarcinoma in CXCR4+/− mice were larger than that of WT mice, while AMD3100 significantly reduced the number of colonic adenocarcinomas that less than 2 mm or more than 4 mm in diameter (Fig. 1f, g). Here, CXCR4 is linked to neoplasm.