To explore the potential miRNAs and related lncRNAs that play an important role in CXCL12/CXCR4-induced invasion and metastasis of CRC, we screened the differentially expressed miRNAs upon the activation of CXCL12/CXCR4 axis in CRC cell models. The gene discussed is CXCL12; the disease is colorectal carcinoma.