At least 121 genes were significantly upregulated by infection in the R line of the TSF flock, such as adiponectin, C1Q and collagen domain containing (AdipoQ), annexin A1 (ANXA1) and ANXA 3, various complement related genes (CFI, C1QA, C1QB, C1QC, and C1S), and integrin subunit alpha 1 (ITGA1) and ITGA3. The gene discussed is ANXA1; the disease is infection.