CD274 and neoplasm: For instance, while assessment of PD-L1 expression in advanced gastric cancer or gastroesophageal junction adenocarcinoma samples by the PD-L1 IHC 22C3 pharmDx assay uses a “combined positive score” or CPS [6], testing metastatic non-small cell lung cancer (NSCLC) patient samples relies on a “tumor proportion score” or TPS [7].