FOLR1 and neoplasm: For instance, in ovarian cancer models, MORAB-003 (farletuzumab), a humanized monoclonal antibody against folate receptor alpha (FRα), has displayed a notable anti-tumor effect through antibody-dependent cellular cytotoxicity by sustaining late-stage autophagy, and when protein and organelle turnover overwhelm the capacity of the cell, which contributes to type II programmed cell death or autophagic death [162, 163].