There is evidence that enhancement of neutrophil autophagy in hepatocellular carcinoma (HCC) is correlated with the release of matrix metalloproteinase-9 (MMP9) and oncostatin M (OSM), but is unrelated to the deactivation of mTOR signaling, which could contribute to the advanced migration of tumor cells. This evidence concerns the gene MMP9 and hepatocellular carcinoma.