The anti-tumor effects of inhibiting autophagy in multiple tumor types in the context of oncogenic Ras have been reported to be dependent on p53 that suppresses autophagy by inhibiting AMPK, and activating mTOR, suggesting that the loss of the tumor suppressor p53 in the context of oncogenic Ras significantly accelerates tumor cell proliferation [41, 42]. Here, MTOR is linked to neoplasm.