In a model of KRas-driven lung carcinogenesis, autophagy deficiency is induced by knockdown of Atg5 or Atg7, which induces the inopportune recruitment of Treg cells via ENTPD1 (CD39, an ecto-enzyme that is exposed on the cell surface)-mediated conversion of immunostimulatory ATP into immunosuppressive ADP (adenosine diphosphate 1) and AMP (adenosine monophosphate) to suppress the specific anti-tumor responses [90]. Here, ATG5 is linked to neoplasm.