Autophagy enhances the effect of immunotherapy by ensuring an optimal release of immunostimulatory signals via delivering antigens to the immune cells, including antigen-presenting cells and CD8 + cytotoxic T lymphocytes, and hence propels their ability to initiate an immune response, which is indispensable for the activity of several components of the immune system involved in tumor recognition and elimination. This evidence concerns the gene CD8A and neoplasm.