Among these chemoattractants, chemokine [C–C motif] ligand 2 (CCL2) exerts a prominent action in recruiting monocytes and is able to protect monocytes against apoptosis in the tumor microenvironment by upregulating anti-apoptotic proteins and inhibiting CASP8/caspase-8 cleavage, and it also induces hyper-activation of autophagy in TAMs [101]. The gene discussed is CASP8; the disease is neoplasm.