AXIN1 and cervical carcinoma: To further verify whether β-catenin activation was responsible for the NUSAP1-mediated effects, we detected the impact of blocking Wnt/β-catenin pathway on the metastasis and self-renewal capability of cervical cancer cells using the tankyrase inhibitor XAV-939(which was proved to stabilizes axin, a component of the β-catenin destruction complex, and widely used forblocking Wnt pathway) and a β-catenin-short interfering siRNA (Fig. 7a).