Moreover, NUSAP1 induced SUMOylation of TCF4 via interacting with SUMO E3 ligase Ran-binding protein 2 (RanBP2) and potently activated the Wnt/β-catenin signaling pathway, thus contributing to the metastatic and CSC-likeproperties of cervical cancer cells. This evidence concerns the gene RANBP2 and cervical carcinoma.