In particular, the described concurrence of HSPA8 and RyR2 for atrial fibrillation and myocardial infarction, the involvement of DUSP4 in I/R injury, the role of PHLPP2 in developing complications after cardiac surgery and the involvement of BBS9 in renal dysfunction could be interesting for further future examinations. The gene discussed is PHLPP2; the disease is atrial fibrillation.