INS and obesity due to melanocortin 4 receptor deficiency: For example, intermittent administration of a mixture of 14 strains from several genera (Lactobacillus, Lactococcus, Bifidobacterium, Propionibacterium, Acetobacter) on monosodium glutamate (MSG)-induced obesity mouse model caused a significant reduction in the total body/visceral adipose tissue weight and improved insulin sensitivity compared to controls [117].