MAPK14 and central nervous system cancer: One of the most crucial pathways involved in gliomagenesis is the MAPK pathway which appears to regulate the genesis and the progression of glioma via crucial signaling mediators such as RAF (Rapidly Accelerated Fibrosarcoma), RAS (Rat Sarcoma), Erk, JNK (c-Jun N-terminal kinase) and p38 [16].