One of the most crucial pathways involved in gliomagenesis is the MAPK pathway which appears to regulate the genesis and the progression of glioma via crucial signaling mediators such as RAF (Rapidly Accelerated Fibrosarcoma), RAS (Rat Sarcoma), Erk, JNK (c-Jun N-terminal kinase) and p38 [16]. The gene discussed is MAPK8; the disease is central nervous system cancer.