IFNAR1 and Zika virus infectious disease: We recently demonstrated that anti-ZIKV human polyclonal antibodies (SAB-155) produced from TcB administered at −1 and +1 dpi provided 100% protection against ZIKV infection in wild type mice treated with an anti-interferon receptor antibody and in homozygous Ifnar1 knockout (Ifnar-/-) C57BL/6 mice, and eliminated ZIKV induced tissue damages in the brain and testis [6].