Several mouse models of ZIKV infection, such as the stat2-/- [18], A129 (Ifnar-/-), AG129, Irf3-/-Irf5-/-Irf7-/- triple KO, and WT mice treated with type I IFN-blocking antibody have been reported with a variety of treatment strategies including small molecule antivirals and antibodies [19]. Here, IRF3 is linked to Zika virus infectious disease.