STAT2 KO hamsters exhibited conjunctivitis after ZIKV infection, which was significantly reduced in animals treated prophylactically with SAB-155: 50% (6 out of 12) of the control-antibody treated animals were free of conjunctivitis, while 81% (9 out of 11) of SAB-155 treated animals were free of eye disease (Figure 2C). This evidence concerns the gene SH3BP5 and Zika virus infectious disease.