In order to evaluate the prophylactic efficacy of SAB-155 in protecting STAT2 KO hamsters from ZIKV infection, equal numbers of age-matched male (n = 6) and female (n = 6) hamsters (6-weeks of age) were prophylactically treated by a single i.p injection of 100 mg/kg SAB-155 one day prior to ZIKV infection. Here, STAT2 is linked to Zika virus infectious disease.