High secretion of tumor necrosis factor-alpha (TNF-α) [7], interleukin-6 (IL-6) [8], monocyte chemoattractant protein-1 (MCP-1) [9], and additional products of macrophages [10] by adipose tissue with low sensitivity to insulin has also been detected in obesity. Here, INS is linked to obesity due to melanocortin 4 receptor deficiency.