AKT1 and hepatocellular carcinoma: These effects are associated with the inactivation of PI3K/AKT/β-catenin signaling that is mediated by targeting MARCH1, which further induces the loss of Mcl-1 and Bcl-2, leading to accumulation of caspase family member proteins to suppress HCC proliferation, migration, and invasion and to induce cell cycle arrest and apoptosis.