These effects are associated with the inactivation of PI3K/AKT/β-catenin signaling that is mediated by targeting MARCH1, which further induces the loss of Mcl-1 and Bcl-2, leading to accumulation of caspase family member proteins to suppress HCC proliferation, migration, and invasion and to induce cell cycle arrest and apoptosis. This evidence concerns the gene MCL1 and hepatocellular carcinoma.