Both the PI3K/AKT/mTOR and the Wnt/β-catenin signaling cascades are known to be important canonical signaling pathways involved in tumor development and progression; approximately 50% of HCC cases display aberrantly activated PI3K/AKT/mTOR and Wnt/β-catenin signaling [13]. The gene discussed is MTOR; the disease is hepatocellular carcinoma.