Although it is well known that activation of VEGF-A mediated by (HIF-1α)-induced miRNAs (HRMs) plays a key role in cerebral ischemia, and the HMRs miR-195-5p and miR-451a have been shown to target VEGF-A factor in several experimental settings [23,24,25,26,27,28], no clinical study investigated the exact correlation between their expression, the HIF-1 expression and the outcomes of AIS and TIA patients. This evidence concerns the gene VEGFA and brain ischemia.