However, the available data indicate that T-cells undergo a similar activation profile in CCHFV-challenged humanized mice and RVFV-challenged C57BL/6 mice [144,145], T-cells are important for protection after RVFV challenge in mice [145,146], whereas in human beings, these infections can induce long-lived memory CD8+ T-cells [147]. The gene discussed is CD8A; the disease is infection.