In patients with HPS caused by Sin Nombre Virus (SNV), CD8+ T-cells recognize epitopes on the viral nucleocapsid protein restricted by HLA-C7 and HLA-B35, whereas CD4+ T-cells recognize epitopes on the viral nucleocapsid protein restricted by HLA-DQw2 or DR3 [149]. The gene discussed is CD8A; the disease is Hermansky-Pudlak syndrome.