As zearalenone and apigenin activated ERs, we tested the potential effect of these molecules on the expression of endogenous E2-dependent genes, such as the chemokine CXCL12, the progesterone receptor (PgR), amphiregulin (AREG) and growth regulation in breast cancer 1 (GREB1) (Figure 3). The gene discussed is CXCL12; the disease is breast cancer.