ATG5 and acute myeloid leukemia: Interestingly, other reports showed that ATG5 or ATG7 are required for the efficient initiation of AML in the context of MLL-AF9, the most common alteration found in infant AML, with poor prognosis, but that autophagy is no longer needed for the maintenance of established AML or LSC functions in secondary xenotransplantation experiments [54,118,119,120].