B-ALL patients with the ETV6-RUX1 translocation have significantly increased expression of the autophagy initiating lipidase VPS34 compared to normal hematopoietic stem/progenitor cells, and the presence of the ETV6-RUNX1 fusion protein was found to have a causal relationship to VPS34 overexpression through epigenetic regulation [131]. Here, PIK3C3 is linked to acute lymphoblastic leukemia.