ATG4B and chronic myelogenous leukemia, BCR-ABL1 positive: Key enzymes in the LC3 conjugation cascade, such as ATG7 and ATG4B, have both been implicated as critical for CD34+ CML cell survival, while genetic inhibition of ATG4B or ATG7 was able to increase apoptosis of CML stem and progenitor cells and sensitize them to TKIs [6,28].