KMT2A and acute myeloid leukemia: Disruption of functional autophagy can lead to efficient initiation and more aggressive disease progressions, for instance in MLL-mutated AML cells, but the autophagy process may also stabilize oncogenic drivers such as FLT3-ITD, which is elevated in poor risk primary AML patient cells and most importantly, ensures survival of leukemic blasts and LSCs upon chemotherapy.