ATG7 and acute myeloid leukemia: However, by combining chemotherapy with ATG7 depletion or CQ/HCQ/Bafilomycin A1 treatment to block autophagy, the therapeutic effects of AraC or cytarabine could be enhanced and cell death promoted, even in drug-resistant cells and the LSC population [54,119,121,122,147,148], suggesting that the autophagy process is critically involved in treatment response/resistance of AML cells.