Although the biological effects of the ATG4B antagonist NSC185058 have not been described in hematological malignancies, it was recently reported that it can suppress the activation and lipidation of LC3B and the degradation of p62/SQSTM1, which result in significantly reduced cell viability and xenograft growth in vitro and in vivo when combined with CQ in a glioblastoma model [83]. Here, SQSTM1 is linked to hematologic disorder.