The identification of BCR-ABL1 as the major driver in the pathogenesis of CML led to the development of targeted therapies with ABL1 tyrosine kinase inhibitors (TKIs) such as Imatinib, Dasatinib, and Ponatinib [58,59]. This evidence concerns the gene ABL1 and chronic myelogenous leukemia, BCR-ABL1 positive.