Our observations also suggest that the components Roseo and IE4, isolated and purified from NA, may independently suppress hypertension-related molecules such as ROS, cytokines and chemokines, and TGF-β, which are typically associated with oxidative stress, inflammation, and vascular remodeling in hypertension, by increasing endogenous anti-oxidant enzymes in Ang II-stimulated H9C2 cells. The gene discussed is TGFB1; the disease is hypertensive disorder.