MAPT and dementia: Alzheimer’s disease (AD) was first found and named by Alois Alzheimer in 1906 [1]; it accounts for 50–60% of all forms of dementia and is characterized by the extracellular deposition of amyloid plaques consisting of amyloid-β (Aβ) peptides [2], abnormally hyperphosphorylated tau (p-tau) containing intracellular neurofibrillary tangles (NFTs) [3], and neuronal cell death.