This neuroprotective mechanism of ST extract against MPTP-induced Parkinsonism, which was the same as protocatechuic acid, might be related to decreasing the phosphorylation of GSK-3β and restoring the activities of striatal antioxidant defenses to restore the nigrostriatal dopaminergic function and decrease α-synuclein accumulation. Here, GSK3B is linked to Parkinsonism.