While Cdk-dependent phosphorylation of Prdx has been more comprehensively detailed for Prdx1, evidence of Prdx2 targeting by Cdk5/p35 and Cdk5/p25 complexes was described to reduce peroxidase activity and cause neuronal death in a toxin-induced model of Parkinson’s disease [94]. Here, CDK5 is linked to Parkinson disease.