Using microarray datasets for associations between SSX2IP and the genes involved in spindle checkpoints described by Boyapati et al., Guinn et al. [73] found a strong correlation between low-CDC20 expression, one of the substrate-targeting subunits of the anaphase-promoting complex and low-SSX2IP expression in patients harbouring a t(8;21) translocation when compared with AML patients without a t(8;21) translocation and normal donors. The gene discussed is SSX2IP; the disease is acute myeloid leukemia.