There are a number of different types of antigens [32], including differentiation, mutated, overexpressed, and cancer-testis antigens (CTAs), some of which have been found in AML, including antigens from mutated genes such as Nucleophosmin 1 (NPM1), DNA methyltansferase 3A (DNMT3A), Fms Related Tyrosine Kinase 3 (FLT3), and Ten–Eleven Translocation 2 (TET2) (recently reviewed by [33]). Here, NPM1 is linked to cancer.