SPP1 and lung cancer: Two concomitant studies of nested patient samples, the Japan-Multinational Trial Organization (JMTO) Lung Cancer (LC) 0004 in the Japanese population and the SouthWest Oncology Group (SWOG) 0003 in the US population, obtained the same evidence regarding the prognostic significance of circulating osteopontin in advanced non-small-cell lung cancers [60,61].