Bockelman and colleagues [66] measured MMP-8, MMP-9, and TIMP-1 in serum from CRC patients within 30 days prior to surgery and found that MMP-8 and TIMP-1 alone served as prognostic factors, high levels of which correlated significantly with worse five-year disease-specific survival (DSS). Here, MMP8 is linked to colorectal carcinoma.