As mentioned in the introduction, ANXA8 was found upregulated in acute promyelocytic leukemia (APL) carrying the dominant negative PML-RARA mutant, that, by inhibiting the RA- regulated normal RARA transcriptional function, blocks myeloid differentiation [25], and it is associated with a restricted signature of few miRNAs (e.g., miR-342-3p), that discriminates APL myeloblasts from normal promyelocytes [23]. The gene discussed is PML; the disease is acute promyelocytic leukemia.