In previous studies we found a restricted protein signature of 42 proteins including 22 upregulated proteins shared by five HME1 “DCIS-precursor” lines with different genetic mutations that increased the expression of ANXA8, a Ca2+ and phospholipid binding protein, which is regulated by all-trans Retinoic Acid (RA) [24]. The gene discussed is ANXA8; the disease is ductal breast carcinoma in situ.