Mast cells may promote inflammation, inhibition of tumor cell growth, and tumor cell apoptosis by releasing cytokines, such as IL-1, IL-4, IL-6, IL-8, monocyte chemotactic protein-3 and -4 (MCP-3 and MCP-4), transforming growth factor beta (TGF-β), and chymase. The gene discussed is CMA1; the disease is neoplasm.