As investigations on the APOE polymorphism get performed considering human subjects with earlier age in life, the possible influence of each APOE genotype in these younger populations should consider that APOE2 and APOE4 can be part of AP phenomena occurring in the same individual (e.g. APOE2/E4) and across different individuals (e.g. APOE3/E2 vs. APOE3/E4) at different ages. The gene discussed is APOE; the disease is alkaline phosphatase measurement.