In support of the hypothesis that APOE4-related effects could be linked to different pathomechanisms than the ones leading to neurodegeneration when considering short- or long-term outcomes in the context of the same disease, for example traumatic brain injury (TBI) where there are data showing the possible association between APOE and post-concussive syndrome in children, which do not have any significant difference between APOE4- vs. non-APOE4 carriers, in particular when immediate or short-term outcomes are considered [154]. This evidence concerns the gene APOE and post-concussion syndrome.